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Article

Alzheimer's disease as an innate autoimmune disease (AD2): A new molecular paradigm

27 Sept 2022

Abstract excerpt

Abstract A new model of Alzheimer's disease (AD) is presented: Alzheimer's disease as an autoimmune disease (AD2). In response to pathogen‐/damage‐associated molecular pattern‐stimulating events (e.g., infection, trauma, ischemia, pollution), amyloid beta (Aβ) is released as an early responder cytokine triggering an innate immunity cascade in which Aβ exhibits immunomodulatory/antimicrobial duality. However, Aβ’s...

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PMID: 36165334
DOI: 10.1002/alz.12789

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