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Article

Altered microbial biogeography in an innate model of colitis

26 Sept 2022

Abstract excerpt

Changes in the spatial organization, or biogeography, of colonic microbes have been observed in human inflammatory bowel disease (IBD) and mouse models of IBD. We have developed a mouse model of IBD that occurs spontaneously and consistently in the absence of adaptive immunity. Mice expressing tumor necrosis factor-induced protein 3 (TNFAIP3) in intestinal epithelial cells (villin-TNFAIP3) develop colitis when...

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PMID: 36162004
DOI: 10.1080/19490976.2022.2123677

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