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Article

Small-scale manufacturing of neoantigen-encoding messenger RNA for early-phase clinical trials

22 Oct 2021

Abstract excerpt

Messenger RNA (mRNA) has become a promising tool in therapeutic cancer vaccine strategies. Owing to its flexible design and rapid production, mRNA is an attractive antigen delivery format for cancer vaccines targeting mutated peptides expressed in a tumor—the so-called neoantigens. These neoantigens are rarely shared between patients, and inclusion of these antigens in a vaccine requires the production of...

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PMID: 34696961
DOI: 10.1016/j.jcyt.2021.08.005

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