Article
The "steric-like" inhibitory effect and mechanism of doxycycline on florfenicol metabolism: Interaction risk.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Nov 2022
Xu Xiaoqing, Liu Yanan, Guo Mingyue, Martínez María-Aránzazu, Ares Irma, Lopez-Torres Bernardo, Martínez-Larrañaga María-Rosa, Wang Xu, Anadón Arturo, Martínez Marta
Abstract excerpt
Most of the studies on doxycycline (DOX) and florfenicol (FF) remain focused on the improvement of antimicrobial activity and antimicrobial spectrum, and there is no relevant report on whether there is interaction between the two drugs after the combination. This research study evaluated the effect of DOX on FF metabolism in vitro and its mechanisms. The findings of this study showed that DOX inhibits FF...
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