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Analysis of fks1 and fks2 gene mutations in invasive Candida glabrata strains from Pakistan.

Mycoses - 1 Jan 2023

Memon Saba, Ghanchi Najia Karim, Zafar Urooj, Farooqi Joveria, Zaka Sadaf, Jabeen Kauser

Abstract excerpt

INTRODUCTION: The gradual increase in caspofungin usage in Pakistan raises a concern of emergence of echinocandin resistance in local Candida glabrata strains. We sequenced and determined mutations in fks1 and fks2 genes in invasive Candida glabrata strains from Pakistan. MATERIAL AND METHODS: Thirty-six invasive C. glabrata strains were selected with median (min-max) minimum inhibitory concentrations (MICs) of...

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PMID: 36106428
DOI: 10.1111/myc.13527

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