Substratum interactions modulate interplay between endothelial cell, epithelial cell, and fibroblast phenotype and immunomodulatory function.

Abstract excerpt

Endothelial cells (ECs) sense and adapt to their environment, allowing them to display a range of functional phenotypes and promote vascular homeostasis across organ systems. However, many of these cues are lost when cells are cultured in vitro. This work explores how substratum interactions influence cellular phenotype. Culture conditions, specifically 2D culture on tissue culture polystyrene (TCP) versus 3D...

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