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Immunologically “cold” triple negative breast cancers engraft at a higher rate in patient derived xenografts

10 Sept 2022

Abstract excerpt

TNBC is a heterogeneous subtype of breast cancer, and only a subset of TNBC can be established as PDXs. Here, we show that there is an engraftment bias toward TNBC with low levels of immune cell infiltration. Additionally, TNBC that failed to engraft show gene expression consistent with a cancer-promoting immunological state, leading us to hypothesize that the immunological state of the tumor and possibly the...

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PMID: 36088362
DOI: 10.1038/s41523-022-00476-0

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