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A gene expression profile for the lower osteogenic potent of bone-derived MSCs from osteoporosis with T2DM and the potential mechanism

1 Sept 2022

Abstract excerpt

BACKGROUND: Osteoporosis (OP) patients complicated with type II diabetes mellitus (T2DM) has a higher fracture risk than the non-diabetic patients, and mesenchymal stem cells (MSCs) from T2DM patients also show a weaker osteogenic potent. The present study aimed to provide a gene expression profile in MSCs from diabetic OP and investigated the potential mechanism. METHODS: The bone-derived MSC (BMSC) was isolated...

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Bone Metabolism and Diseases
FOXO transcription factor regulation
Mesenchymal stem cell research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36050744
DOI: 10.1186/s13018-022-03291-2

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