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Valtrate antagonizes malignant phenotypes of lung cancer cells by reducing SLC7A11.

Human & experimental toxicology - 1 Jan 2000

Xu Wei, Yu Huan

Abstract excerpt

OBJECTIVES: This research explored the efficacy of valtrate (Val) in lung cancer (LC). METHODS: A549 and H1299 cells were dealt with Val. SLC7A11 was overexpressed by cell transfection. Xenograft model was established in nude mice. Cell viability, proliferation and apoptosis were measured by CCK-8, EdU and Annexin-V and propidium iodide staining, respectively. Ferroptosis was assessed by iron assay kit. reactive...

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Lung Neoplasms
Mice
Mice, Nude
Phenotype
Reactive Oxygen Species

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PMID: 36048842
DOI: 10.1177/09603271221124096

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