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Article

Safety analysis of glecaprevir/pibrentasvir in patients with markers of advanced liver disease in clinical and real-world cohorts.

Journal of viral hepatitis - 1 Dec 2022

Feld Jordan J, Forns Xavier, Dylla Douglas E, Kumada Hiromitsu, de Ledinghen Victor, Wei Lai, Brown Robert S, Flisiak Robert, Lampertico Pietro, Thabut Dominique, Bondin Mark, Tatsch Fernando, Burroughs Margaret, Marcinak John, Zhang Zhenzhen, Emmett Amanda, Jacobson Ira M

Abstract excerpt

Chronic hepatitis C virus (HCV) infection has the greatest health impact in patients with advanced liver disease. The direct-acting antiviral (DAA) regimen glecaprevir/pibrentasvir (G/P) is approved for treatment of HCV-infected patients without cirrhosis and with compensated cirrhosis. However, events of liver decompensation/failure have been reported in patients treated with protease-inhibitor-containing DAA...

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Identifiers

PMID: 36036117
DOI: 10.1111/jvh.13738
PMCID: PMC9827821

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