Glecaprevir plus pibrentasvir for chronic hepatitis C virus genotype 1, 2, 4, 5, or 6 infection in adults with compensated cirrhosis (EXPEDITION-1): a single-arm, open-label, multicentre phase 3 trial.

doi:10.1016/S1473-3099(17)30496-6

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Glecaprevir plus pibrentasvir for chronic hepatitis C virus genotype 1, 2, 4, 5, or 6 infection in adults with compensated cirrhosis (EXPEDITION-1): a single-arm, open-label, multicentre phase 3 trial.

The Lancet. Infectious diseases - 1 Oct 2017

Forns Xavier, Lee Samuel S, Valdes Joaquin, Lens Sabela, Ghalib Reem, Aguilar Humberto, Felizarta Franco, Hassanein Tarek, Hinrichsen Holger, Rincon Diego, Morillas Rosa, Zeuzem Stefan, Horsmans Yves, Nelson David R, Yu Yao, Krishnan Preethi, Lin Chih-Wei, Kort Jens J, Mensa Federico J

Abstract excerpt

BACKGROUND: The once-daily, ribavirin-free, pangenotypic, direct-acting antiviral regimen, glecaprevir coformulated with pibrentasvir, has shown high rates of sustained virological response in phase 2 and 3 studies. We aimed to assess the efficacy and safety of 12 weeks of coformulated glecaprevir and pibrentasvir in patients with hepatitis C virus (HCV) infection and compensated cirrhosis. METHODS: We did this...

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PMID: 28818546
DOI: 10.1016/S1473-3099(17)30496-6

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