Safety and Effectiveness Using 8 Weeks of Glecaprevir/Pibrentasvir in HCV-Infected Treatment-Naïve Patients with Compensated Cirrhosis: The CREST Study.

doi:10.1007/s12325-022-02158-6

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Article

Safety and Effectiveness Using 8 Weeks of Glecaprevir/Pibrentasvir in HCV-Infected Treatment-Naïve Patients with Compensated Cirrhosis: The CREST Study.

Advances in therapy - 1 Jul 2022

Cornberg Markus, Ahumada Adriana, Aghemo Alessio, Andreoni Massimo, Bhagat Abhi, Butrymowicz Isabel, Carmiel Michal, Chodick Gabriel, Conway Brian, Song Yanna, Gasbarrini Antonio, Hüppe Dietrich, Plaza Francisco Jorquera, Lampertico Pietro, Alonso Maria Luisa Manzano, Myles Lindsay, Persico Marcello, Ramji Alnoor, Sarrazin Christoph, Villa Erica, Weil Clara, Otano Juan Isidro Uriz

Abstract excerpt

INTRODUCTION: In clinical trials with hepatitis C virus-infected treatment-naïve (TN) patients with compensated cirrhosis (CC), glecaprevir/pibrentasvir (G/P), a fixed-dose, once-daily, pangenotypic regimen, has demonstrated sustained virologic response at posttreatment Week 12 (SVR12) > 95%. We evaluated the real-world safety and effectiveness of 8-week G/P therapy in TN patients with CC, including certain...

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PMID: 35543964
DOI: 10.1007/s12325-022-02158-6
PMCID: PMC9239949

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