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Article

Familial and hereditary gastric cancer, an overview.

Best practice & research. Clinical gastroenterology - 1 Jan 2000

Carneiro Fátima

Abstract excerpt

There are three major hereditable syndromes that affect primarily the stomach: hereditary diffuse gastric cancer (HDGC), gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) and familial intestinal gastric cancer (FIGC). HDGC is caused by germline mutations in CDH1 gene that occur in 10-40% of HDGC families and, in a minority of cases, by mutations in CTNNA1 gene. GAPPS is caused by germline...

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Identifiers

PMID: 35988963
DOI: 10.1016/j.bpg.2022.101800

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