Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Long non-coding RNA LINC00665 promotes gemcitabine resistance of Cholangiocarcinoma cells via regulating EMT and stemness properties through miR-424-5p/BCL9L axis

12 Jan 2021

Abstract excerpt

Gemcitabine is the first-line chemotherapy drug for cholangiocarcinoma (CCA), but acquired resistance has been frequently observed in CCA patients. To search for potential long noncoding RNAs (lncRNAs) involved in gemcitabine resistance, two gemcitabine resistant CCA cell lines were established and dysregulated lncRNAs were identified by lncRNA microarray. Long intergenic non-protein coding RNA 665 (LINC00665)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related molecular mechanisms research
Share to Cholangiocarcinoma and Gallbladder Cancer Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to RNA modifications and cancer

Source

Identifiers

PMID: 33436545
DOI: 10.1038/s41419-020-03346-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Long non-coding RNA LINC00665 promotes gemcitabine resistance of Cholangiocarcinoma cells via regulating EMT and stemness properties through miR-424-5p/BCL9L axisPMID 33436545Read ↗

Long noncoding RNA LINC01296 promotes tumor growth and progression by sponging miR-5095 in human cholangiocarcinomaSemantic proximity Read ↗

Role of the long non-coding RNAs in regulation of Gemcitabine response in tumor cellsSemantic proximity Read ↗

LINC00665 contributes to cholangiocarcinoma progression by modulating IRF1/PD-L1Semantic proximity Read ↗

Long non-coding RNA LINC00152 regulates cell proliferation and migration by epigenetically repressing LRIG1 expression in cholangiocarcinomaSemantic proximity Read ↗

LINC01714 Enhances Gemcitabine Sensitivity by Modulating FOXO3 Phosphorylation in CholangiocarcinomaSemantic proximity Read ↗

The Advancement of Long Non-Coding RNAs in Cholangiocarcinoma DevelopmentSemantic proximity Read ↗

YY1-induced DLEU1/miR-149-5p Promotes Malignant Biological Behavior of Cholangiocarcinoma through Upregulating YAP1/TEAD2/SOX2Semantic proximity Read ↗

Emerging roles of long noncoding RNAs in cholangiocarcinoma: Advances and challengesSemantic proximity Read ↗

Clinical Significance of LINC00261 in the pathogenesis of Pancreatic, Colorectal, Hepatocellular, and Gallbladder CancerSemantic proximity Read ↗

LINC00662 Promotes Aggressive Traits by Modulating OCT4 Expression through miR-335-5p in Gallbladder Cancer CellsSemantic proximity Read ↗

Non-coding RNA and Drug resistance in cholangiocarcinomaSemantic proximity Read ↗

PSMA3-AS1 induced by transcription factor PAX5 promotes cholangiocarcinoma proliferation, migration and invasion by sponging miR-376a-3p to up-regulate LAMC1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.