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Various impacts of driver mutations on the PD-L1 expression of NSCLC.

PloS one - 1 Jan 2022

Chu Cheng-Hsiang, Huang Yen-Hsiang, Lee Po-Hsin, Hsu Kuo-Hsuan, Chen Kun-Chieh, Su Kang-Yi, Yu Sung-Liang, Tseng Jeng-Sen, Yang Tsung-Ying, Chang Gee-Chen

Abstract excerpt

We aimed to evaluate whether different driver mutations have varying impacts on the programmed cell death-ligand 1 (PD-L1) expression of non-small cell lung cancer (NSCLC), and whether the prognostic roles of PD-L1 amongst our patients were divergent. This was a single-institute study that included patients with NSCLC. Six driver mutations, PD-L1 status, and the outcomes of treatment were assessed. A total of...

Topics

Anaplastic Lymphoma Kinase
B7-H1 Antigen
Carcinoma, Non-Small-Cell Lung
Humans
Lung Neoplasms
Mutation
Protein-Tyrosine Kinases
Proto-Oncogene Proteins
Proto-Oncogene Proteins p21(ras)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35980949
DOI: 10.1371/journal.pone.0273207
PMCID: PMC9387808

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