Article
The correlation between programmed death-ligand 1 expression and driver gene mutations in NSCLC.
Oncotarget - 4 Apr 2017
Yang Haitao, Chen Huijuan, Luo Shuimei, Li Lina, Zhou Sijing, Shen Ruifen, Lin Heng, Xie Xianhe
Abstract excerpt
OBJECTIVES: This study aimed to evaluate the correlation between positive PD-L1 expression and driver gene mutations in NSCLC and to seek preliminary evidence in favor of the strategy of PD-L1 inhibitors plus targeted agents. RESULTS: The overall analyses revealed that positive PD-L1 expression had a significant relationship with KRAS status (RR = 1.26; 95% CI, 1.06-1.50, P = 0.010), but no correlation with...
Topics
- Anaplastic Lymphoma Kinase
- Asian People
- B7-H1 Antigen
- Carcinoma, Non-Small-Cell Lung
- China
- Disease-Free Survival
- ErbB Receptors
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Lung Neoplasms