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Article

HUS with mutations in CFH and STEC infection treated with eculizumab in a 4-year-old girl.

Pediatric nephrology (Berlin, Germany) - 1 Apr 2023

Galvez Carla, Krall Paola, Rojas Alejandro, Oh Jun, Cano Francisco

Abstract excerpt

BACKGROUND: Hemolytic uremic syndrome secondary to Shiga-toxin-producing Escherichia coli infection (STEC-HUS) generally shows a favorable outcome. Few cases develop extra-renal complications, since neurological involvement is an important cause of morbidity and mortality. The role of complement in STEC-HUS has been recently highlighted, and the use of eculizumab in severe cases has been communicated. HUS results...

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PMID: 35969277
DOI: 10.1007/s00467-022-05694-z

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