Article
Quantifying epithelial-mesenchymal heterogeneity and EMT scoring in tumor samples via tyramide signal amplification (TSA).
Methods in cell biology - 1 Jan 2022
Brown Meredith S, Abdollahi Behnaz, Hassanpour Saeed, Pattabiraman Diwakar R
Abstract excerpt
Tumor heterogeneity presents an ongoing challenge to disease progression and treatment in many solid tumor types. Understanding the roots of intra-tumoral heterogeneity and how it may relate to the high incidence of metastasis is critical in overcoming disease relapse and chemoresistance. The epithelial-to-mesenchymal transition is a dynamic cellular program that is co-opted by cancer cells to enhance, among...
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