Article
Integrated metagenomic and metabolomic analysis reveals distinct gut-microbiome-derived phenotypes in early-onset colorectal cancer.
Gut - 1 Jun 2023
Kong Cheng, Liang Lei, Liu Guang, Du Lutao, Yang Yongzhi, Liu Jianqiang, Shi Debing, Li Xinxiang, Ma Yanlei
Abstract excerpt
OBJECTIVE: The incidence of early-onset colorectal cancer (EO-CRC) is steadily increasing. Here, we aimed to characterise the interactions between gut microbiome, metabolites and microbial enzymes in EO-CRC patients and evaluate their potential as non-invasive biomarkers for EO-CRC. DESIGN: We performed metagenomic and metabolomic analyses, identified multiomics markers and constructed CRC classifiers for the...
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