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5,6‐Dihydroxyindole eumelanin content in human skin with varying degrees of constitutive pigmentation

7 Aug 2022

Abstract excerpt

Human skin contains two distinct components: brown to black, insoluble eumelanin and light colored, alkaline-soluble pheomelanin. Eumelanin consists of 5,6-dihydroxyindole (DHI) and 5,6-dihydroxyindole-2-carboxylic acid (DHICA) moieties, while pheomelanin consists of benzothiazine (BT) and benzothiazole (BZ) moieties. These melanin monomer units can be quantitatively analyzed through specific degradation products...

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PMID: 35933709
DOI: 10.1111/pcmr.13062

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