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Article

Metabolism of melatonin in the skin: Why is it important?

Experimental dermatology - 1 Jul 2017

Slominski Andrzej T, Semak Igor, Fischer Tobias W, Kim Tae-Kang, Kleszczyński Konrad, Hardeland Ruediger, Reiter Russel J

Abstract excerpt

Melatonin is produced in almost all living taxa and is probably 2-3 billion years old. Its pleiotropic activities are related to its local concentration that is secondary to its local synthesis, delivery from distant sites and metabolic or non-enzymatic consumption. This consumption generates metabolites through indolic, kynuric and cytochrome P450 (CYP) mediated hydroxylations and O-demethylation or...

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Identifiers

PMID: 27619234
DOI: 10.1111/exd.13208
PMCID: PMC5348284

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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