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Prebiotic galactooligosaccharides interact with mouse gut microbiota to attenuate acute graft-versus-host disease

5 Aug 2022

Abstract excerpt

Previous studies suggest that gut microbiome disruption induced by chemotherapy, dietary deficiencies, and/or antibiotics are associated with increased incidence of acute graft-versus-host disease (aGVHD) following hematopoietic stem cell transplantation (HSCT). In a murine model of antibiotic-induced gut microbiome disruption, Holmes and colleagues show that oral administration of galactooligosaccharides (GOS)...

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PMID: 35930748
DOI: 10.1182/blood.2021015178

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