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Article

Novel splice‑site variants c.393G>A, c.278_2A>G in exon 2 and Q705K variant in exon 3 of NLRP3 gene are associated with bipolar I disorder.

Molecular medicine reports - 1 Sept 2022

Öztürk Kuyaş Heki̇mler, Ünal Güli̇n Özdamar

Abstract excerpt

NOD‑like receptor pyrin domain‑containing 3 (NLRP3) has been considered to play a crucial role in triggering the host's immune and inflammatory responses. Genetic variants are critical determinants of interindividual variances in inflammatory responses and clinical outcomes. The role of NLRP3 gene variations in bipolar I (BPI) disorder, which is known to include genetic factors in its aetiology, has not been...

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Identifiers

PMID: 35920179
DOI: 10.3892/mmr.2022.12810
PMCID: PMC9366148

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