Article
Juvenile patients with the homozygous MTHFR C677T genotype develop ischemic stroke 5 years earlier than wild type.
Journal of thrombosis and thrombolysis - 1 Aug 2022
Ames Paul R J, D'Andrea Giovanna, Marottoli Vincenzo, Arcaro Alessia, Iannaccone Luigi, Gentile Fabrizio, Maraglione Maurizio
Abstract excerpt
To compare age at 1st ischaemic stroke (IS) in a cohort of juvenile (< 46 years of age) IS patients evaluated for the rs1801133 polymorphism (C → T677) of the methylene tetrahydrofolate reductase (MTHFR) gene; to identify predictors of age at IS and of type of cerebral vessel involvement, small vessel disease (SVD) vs large vessel disease (LVD) responsible for the IS; to evaluate possible associations between...
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