Article
Genetic interaction between Scn8a and potassium channel genes Kcna1 and Kcnq2.
Epilepsia - 1 Oct 2022
Hill Sophie F, Ziobro Julie M, Jafar-Nejad Paymaan, Rigo Frank, Meisler Miriam H
Abstract excerpt
Voltage-gated sodium and potassium channels regulate the initiation and termination of neuronal action potentials. Gain-of-function mutations of sodium channel Scn8a and loss-of-function mutations of potassium channels Kcna1 and Kcnq2 increase neuronal activity and lead to seizure disorders. We tested the hypothesis that reducing the expression of Scn8a would compensate for loss-of-function mutations of Kcna1 or...
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