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Article

The screening for anticoagulant rodenticide gene VKORC1 polymorphism in the rat Rattus norvegicus, Rattus tanezumi and Rattus losea in Hong Kong.

Scientific reports - 22 Jul 2022

Huang Elaine Y Y, Law Sean T S, Nong Wenyan, Yip Ho Yin, Uea-Anuwong Theethawat, Magouras Ioannis, Hui Jerome H L

Abstract excerpt

Anticoagulants are a major component of rodenticides used worldwide, which function by effectively blocking the vitamin K cycle in rodents. The rat Vitamin K epoxide Reductase Complex (VKORC) subunit 1 is the enzyme responsible for recycling vitamin K, and five substitution mutations (Tyr139Cys, Tyr139Ser, Tyr139Phe and Leu128Gln and Leu120Gln) located in the VKORC1 could result in resistance to anticoagulant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35869096
DOI: 10.1038/s41598-022-16550-3
PMCID: PMC9307595

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