Article
Allele-specific activation, enzyme kinetics, and inhibitor sensitivities of EGFR exon 19 deletion mutations in lung cancer.
Proceedings of the National Academy of Sciences of the United States of America - 26 Jul 2022
Brown Benjamin P, Zhang Yun-Kai, Kim Soyeon, Finneran Patrick, Yan Yingjun, Du Zhenfang, Kim Jiyoon, Hartzler Abigail Leigh, LeNoue-Newton Michele L, Smith Adam W, Meiler Jens, Lovly Christine M
Abstract excerpt
Oncogenic mutations within the epidermal growth factor receptor (EGFR) are found in 15 to 30% of all non-small-cell lung carcinomas. The term exon 19 deletion (ex19del) is collectively used to refer to more than 20 distinct genomic alterations within exon 19 that comprise the most common EGFR mutation subtype in lung cancer. Despite this heterogeneity, clinical treatment decisions are made irrespective of which...
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