Article
Circulating 1,5-Anhydroglucitol as a Biomarker of ß-cell Mass Independent of a Diabetes Phenotype in Human Subjects.
The Journal of clinical endocrinology and metabolism - 28 Sept 2022
Jiménez-Sánchez Cecilia, Mezza Teresa, Sinturel Flore, Li Lingzi, Di Giuseppe Gianfranco, Quero Giuseppe, Jornayvaz François R, Guessous Idris, Dibner Charna, Schrauwen Patrick, Alfieri Sergio, Giaccari Andrea, Maechler Pierre
Abstract excerpt
CONTEXT: During an asymptomatic prediabetic state, the functional ß-cell mass decreases to a critical threshold, triggering diabetes and related symptoms. To date, there are no reliable readouts able to capture in vivo a potential drop of the ß-cell mass. OBJECTIVE: Beside its use as a short-term marker of glycemic control, the deoxyhexose 1,5-anhydroglucitol was identified in rodents as a circulating biomarker...
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