Article
Alterations of NK Cell Phenotype During Pregnancy in Multiple Sclerosis.
Frontiers in immunology - 1 Jan 2022
Wisgalla Anne, Ramien Caren, Streitz Mathias, Schlickeiser Stephan, Lupu Andreea-Roxana, Diemert Anke, Tolosa Eva, Arck Petra C, Bellmann-Strobl Judith, Siebert Nadja, Heesen Christoph, Paul Friedemann, Friese Manuel A, Infante-Duarte Carmen, Gold Stefan M
Abstract excerpt
In multiple sclerosis (MS), relapse rate is decreased by 70-80% in the third trimester of pregnancy. However, the underlying mechanisms driving this effect are poorly understood. Evidence suggests that CD56bright NK cell frequencies increase during pregnancy. Here, we analyze pregnancy-related NK cell shifts in a large longitudinal cohort of pregnant women with and without MS, and provide in-depth phenotyping of...
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