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Article

Predicting mortality among ischemic stroke patients using pathways-derived polygenic risk scores.

Scientific reports - 19 Jul 2022

Li Jiang, Chaudhary Durgesh, Griessenauer Christoph J, Carey David J, Zand Ramin, Abedi Vida

Abstract excerpt

We aim to determine whether ischemic stroke(IS)-related PRSs are also associated with and further predict 3-year all-cause mortality. 1756 IS patients with European ancestry were randomly split into training (n = 1226) and testing (n = 530) groups with 3-year post-event observations. Univariate Cox proportional hazards regression model (CoxPH) was used for primary screening of individual prognostic PRSs. Only the...

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Identifiers

PMID: 35853973
DOI: 10.1038/s41598-022-16510-x
PMCID: PMC9296485

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