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Impact of germline HLA genotypes on clinical outcomes in patients with urothelial cancer treated with pembrolizumab.

Cancer science - 1 Dec 2022

Takahashi Shuhei, Narita Shintaro, Fujiyama Nobuhiro, Hatakeyama Shingo, Kobayashi Takashi, Kato Renpei, Naito Sei, Sakatani Toru, Kashima Soki, Koizumi Atsushi, Yamamoto Ryohei, Nara Taketoshi, Kanda Souhei, Numakura Kazuyuki, Saito Mitsuru, Obara Wataru, Tsuchiya Norihiko, Ohyama Chikara, Ogawa Osamu, Habuchi Tomonori

Abstract excerpt

Human leukocyte antigen class I (HLA-I) genotypes are suggested to influence the cancer response to checkpoint blockade immunotherapy. This study assessed the impact of germline HLA genotypes on clinical outcomes in patients with chemoresistant advanced urothelial cancer (UC) treated with pembrolizumab. Zygosity, supertypes, evolutionary divergency, and specific alleles of germline HLA-I and -II were evaluated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35848083
DOI: 10.1111/cas.15488
PMCID: PMC9746062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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