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Article

RELAY, ramucirumab plus erlotinib versus placebo plus erlotinib in untreated EGFR-mutated metastatic non-small cell lung cancer: exposure-response relationship.

Cancer chemotherapy and pharmacology - 1 Aug 2022

Nakagawa Kazuhiko, Garon Edward B, Gao Ling, Callies Sophie, Zimmermann Annamaria, Walgren Richard, Visseren-Grul Carla, Reck Martin

Abstract excerpt

PURPOSE: In RELAY, ramucirumab plus erlotinib (RAM + ERL) improved progression-free survival (PFS) in patients with untreated, metastatic, EGFR-mutated, non-small cell lung cancer (NSCLC). Here, we present the exposure-response relationship of RAM from RELAY. METHODS: Patients received ERL (150 mg/day) with either RAM (10 mg/kg) or placebo (PBO + ERL) every 2 weeks (Q2W). A population pharmacokinetic model...

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Identifiers

PMID: 35841410
DOI: 10.1007/s00280-022-04447-x
PMCID: PMC9360106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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