A Multicenter Open-Label Randomized Phase II Study of Osimertinib With and Without Ramucirumab in Tyrosine Kinase Inhibitor-Naïve EGFR-Mutant Metastatic Non-Small Cell Lung Cancer (RAMOSE trial).

doi:10.1200/JCO.24.00533

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A Multicenter Open-Label Randomized Phase II Study of Osimertinib With and Without Ramucirumab in Tyrosine Kinase Inhibitor-Naïve EGFR-Mutant Metastatic Non-Small Cell Lung Cancer (RAMOSE trial).

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Feb 2025

Le Xiuning, Patel Jyoti D, Shum Elaine, Baik Christina, Sanborn Rachel E, Shu Catherine A, Kim Chul, Fidler Mary Jo, Hall Richard, Elamin Yasir Y, Tu Janet, Blumenschein George, Zhang Jianjun, Gibbons Don, Gay Carl, Mohindra Nisha A, Chae Young, Boumber Yanis, Sabari Joshua, Santana-Davila Rafael, Rogosin Shane, Herzberg Benjamin, Creelan Ben, Pellini Bruna, Tanvetyanon Tawee, Heeke Simon, Hernandez Mike, Gray Jhanelle E, Saltos Andreas, Heymach John V

Abstract excerpt

PURPOSE: Preclinical studies demonstrated that dual inhibition of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) pathways delay the emergence of resistance to EGFR tyrosine kinase inhibitors (TKIs), and in trials with first-generation EGFR TKIs, the combination of EGFR VEGF pathway inhibitors prolonged progression-free survival (PFS). METHODS: The RAMOSE trial...

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PMID: 39378386
DOI: 10.1200/JCO.24.00533
PMCID: PMC11776886

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