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Increased SORBS3 expression in brain ageing contributes to autophagic decline via YAP1-WWTR1/TAZ signaling

12 Jul 2022

Abstract excerpt

Impaired autophagosome formation and reduced flux through the macroautophagy/autophagy pathway occurs outside the brain as part of normal aging in various species. We recently identified autophagic decline in mouse brain tissue dependent on aging. This sits alongside significantly increased expression of the Sorbs3/SORBS3/vinexin (sorbin and SH3 domain containing 3) gene in older mouse and human brains. We found...

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Share to Autophagy in Disease and Therapy
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PMID: 35822241
DOI: 10.1080/15548627.2022.2100106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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