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Article

Location of EGFR exon 20 insertions matters.

Cancer cell - 11 Jul 2022

Cardona Andrés Felipe, González-Cao María, Arrieta Oscar, Rosell Rafael

Abstract excerpt

EGFR exon 20 insertions represent a subgroup of NSCLC patients posed with a therapy dilemma. In this issue of Cancer Cell, Elamin and colleagues demonstrate that only insertions localized in the near loop respond to poziotinib. Pharmacological inhibition of spindle assembly checkpoint components inhibits tumor growth in poziotinib-resistant exon 20 insertions.

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Identifiers

PMID: 35820394
DOI: 10.1016/j.ccell.2022.06.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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