Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The relationship between phosphodiesterase 4D gene polymorphism and coronary heart disease.

Cellular and molecular biology (Noisy-le-Grand, France) - 27 Feb 2022

Yan Laixing, Li Ketao, Zhang Weiwei, Shen Chengji, Ma Liping, Sun Yu

Abstract excerpt

Coronary atherosclerotic heart disease is one of the most common heart diseases that seriously endanger human health. The study found that intracellular second messenger CAMP plays an important role in inhibiting the proliferation and migration of vascular smooth muscle and the local inflammatory response at the damaged vessel. Phosphodiesterase 4D (PDE4D) can specifically degrade cAMP. The purpose of this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Coronary Artery Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic Nucleotide Phosphodiesterases, Type 4

Share to Gene Frequency

Share to Genetic Predisposition to Disease

Share to Genotype

Share to Polymorphism, Restriction Fragment Length

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 35818218
DOI: 10.14715/cmb/2021.67.6.4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The relationship between phosphodiesterase 4D gene polymorphism and coronary heart disease.PMID 35818218Read ↗

Combination of QTL and GWAS to uncover the role of phosphodiesterases in ischemic heart diseaseSemantic proximity Read ↗

Phosphodiesterase4D (PDE4D)--A risk factor for atrial fibrillation and stroke?Semantic proximity Read ↗

[Research progress on genetic variants of PDE4D and susceptibility to stroke in Chinese population].Semantic proximity Read ↗

Overview of PDEs and their regulation.Semantic proximity Read ↗

Phosphodiesterase 5 and its inhibitors with ischaemic heart disease: a Mendelian randomization analysis and a real-world study.Semantic proximity Read ↗

Relationship of phosphodiesterase 4D (PDE4D) gene polymorphisms with risk of ischemic stroke: a hospital based case-control study.Semantic proximity Read ↗

Features of coronary heart disease development in emergency workers of the Chornobyl accident depending on the action of radiation and non radiation risk factors and genotypes of single nucleotide polymorphism rs966221 of phosphodiesterase 4D gene.Semantic proximity Read ↗

Association of phosphodiesterase 4D gene and interleukin-6 receptor gene polymorphisms with ischemic stroke in a Chinese hypertensive population.Semantic proximity Read ↗

Association of phosphodiesterase 4D gene with ischemic stroke in a Pakistani population.Semantic proximity Read ↗

[Association of rs966221 phosphodiesterase 4D gene's polymorphism with risk of myocardial infarction].Semantic proximity Read ↗

Gender differences in variables associated with dipeptidyl peptidase 4 genetic polymorphisms in coronary artery disease.Semantic proximity Read ↗

Genetic variants of phosphodiesterase 4D gene are associated with an enhanced risk for ischemic stroke in young Chinese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.