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Article

GRN Mutations Are Associated with Lewy Body Dementia.

Movement disorders : official journal of the Movement Disorder Society - 1 Sept 2022

Reho Paolo, Koga Shunsuke, Shah Zalak, Chia Ruth, Rademakers Rosa, Dalgard Clifton L, Boeve Bradley F, Beach Thomas G, Dickson Dennis W, Ross Owen A, Scholz Sonja W

Abstract excerpt

BACKGROUND: Loss-of-function mutations in GRN are a cause of familial frontotemporal dementia, and common variants within the gene have been associated with an increased risk of developing Alzheimer's disease and Parkinson's disease. Although TDP-43-positive inclusions are characteristic of GRN-related neurodegeneration, Lewy body copathology has also been observed in many GRN mutation carriers. OBJECTIVE: The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35810449
DOI: 10.1002/mds.29144
PMCID: PMC9474656

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