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Article

BayesR3 enables fast MCMC blocked processing for largescale multi-trait genomic prediction and QTN mapping analysis.

Communications biology - 5 Jul 2022

Breen Edmond J, MacLeod Iona M, Ho Phuong N, Haile-Mariam Mekonnen, Pryce Jennie E, Thomas Carl D, Daetwyler Hans D, Goddard Michael E

Abstract excerpt

Bayesian methods, such as BayesR, for predicting the genetic value or risk of individuals from their genotypes, such as Single Nucleotide Polymorphisms (SNP), are often implemented using a Markov Chain Monte Carlo (MCMC) process. However, the generation of Markov chains is computationally slow. We introduce a form of blocked Gibbs sampling for estimating SNP effects from Markov chains that greatly reduces...

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PMID: 35790806
DOI: 10.1038/s42003-022-03624-1
PMCID: PMC9256732

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