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Article

SLEMM: million-scale genomic predictions with window-based SNP weighting.

Bioinformatics (Oxford, England) - 1 Mar 2023

Cheng Jian, Maltecca Christian, VanRaden Paul M, O'Connell Jeffrey R, Ma Li, Jiang Jicai

Abstract excerpt

MOTIVATION: The amount of genomic data is increasing exponentially. Using many genotyped and phenotyped individuals for genomic prediction is appealing yet challenging. RESULTS: We present SLEMM (short for Stochastic-Lanczos-Expedited Mixed Models), a new software tool, to address the computational challenge. SLEMM builds on an efficient implementation of the stochastic Lanczos algorithm for REML in a framework...

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PMID: 36897019
DOI: 10.1093/bioinformatics/btad127
PMCID: PMC10039786

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