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Article

Long-term cancer risk in heterozygous familial hypercholesterolemia relatives: a 25-year cohort study.

Lipids in health and disease - 2 Jul 2022

Kjærgaard Kasper Aalbæk, Harborg Sixten, Jensen Henrik Kjærulf, Borgquist Signe

Abstract excerpt

BACKGROUND: Heterozygous familial hypercholesterolemia (HeFH) due to low-density lipoprotein receptor (LDLR) mutations predisposes patients to highly elevated levels of cholesterol, and patients are at increased risk of adverse cardiovascular events and other morbidities. Whether the LDLR mutation and high cholesterol levels affect the risk of cancer remains unknown. The purpose of the present study was to assess...

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Identifiers

PMID: 35780163
DOI: 10.1186/s12944-022-01666-2
PMCID: PMC9250710

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