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Article

Clinical phenotype in relation to the distance-to-index-patient in familial hypercholesterolemia.

Atherosclerosis - 1 Mar 2016

Besseling Joost, Huijgen Roeland, Martin Seth S, Hutten Barbara A, Kastelein John J P, Hovingh G Kees

Abstract excerpt

BACKGROUND AND AIM: We evaluated whether the severity of the familial hypercholesterolemia (FH) phenotype, i.e. increased levels of low-density lipoprotein cholesterol (LDL-C) and cardiovascular disease (CVD) risk, decreases in more distantly related patients within one family. METHODS: We included heterozygous FH patients identified by genetic cascade screening in the Netherlands from 1994 to 2014. A cascade...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26745182
DOI: 10.1016/j.atherosclerosis.2015.12.033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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