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Sp1 induced gene TIMP1 is related to immune cell infiltration in glioblastoma

1 Jul 2022

Abstract excerpt

Tumor immune microenvironment exerts a profound effect on the population of infiltrating immune cells. Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) is frequently overexpressed in a variety of cells, particularly during inflammation and tissue injury. However, its function in cancer and immunity remains enigmatic. In this study, we find that TIMP1 is substantially up-regulated during tumorigenesis...

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PMID: 35778451
DOI: 10.1038/s41598-022-14751-4

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