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Secreted Phosphoprotein 1 (SPP1) Promotes Angiogenesis of Glioblastoma Through Up-regulating PSMA Expression Via Transcription Factor HIF-1α

2022-04-06

Abstract excerpt

<h4>Background: </h4> Glioblastoma multiforme (GBM) is a highly vascular-rich and devastatingly aggressive type of malignant brain tumors, thus anti-angiogenesis therapy plays an essential role in the treatment of GBM. Our previous study had showed that the prostate-specific membrane antigen (PSMA) promoted angiogenesis of GBM through interacting with Integrin β4 (ITGB4) and regulating NF-kB signaling pathway. Thi...

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Literature Corpus work
f875023e-0603-5aed-96b7-b633b866c0cf
DOI
10.21203/rs.3.rs-1266087/v2
Open publication

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