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Article

LRP1B mutation associates with increased tumor mutation burden and inferior prognosis in liver hepatocellular carcinoma.

Medicine - 1 Jul 2022

Yu Ge, Mu Han, Fang Feng, Zhou Hongyuan, Li Huikai, Wu Qiang, Xiong Qingqing, Cui Yunlong

Abstract excerpt

BACKGROUND: Liver hepatocellular carcinoma (LIHC) is the most common primary liver cancer and the main cause of death in patients with cirrhosis. LRP1B is found to involve in a variety of cancers, but the association of LRP1B mutation with tumor mutation burden (TMB) and prognosis of LIHC is rarely studied. METHODS AND RESULTS: Herein, we analyzed the somatic mutation data of 364 LIHC patients from The Cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35777027
DOI: 10.1097/MD.0000000000029763
PMCID: PMC9239668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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