Article
Longitudinal nonlinear mixed effects modeling of EGFR mutations in ctDNA as predictor of disease progression in treatment of EGFR-mutant non-small cell lung cancer.
Clinical and translational science - 1 Aug 2022
Janssen Julie M, Verheijen Remy B, van Duijl Tirsa T, Lin Lishi, van den Heuvel Michel M, Beijnen Jos H, Steeghs Neeltje, van den Broek Daan, Huitema Alwin D R, Dorlo Thomas P C
Abstract excerpt
Correlations between increasing concentrations of circulating tumor DNA (ctDNA) in plasma and disease progression have been shown. A nonlinear mixed effects model to describe the dynamics of epidermal growth factor receptor (EGFR) ctDNA data from patients with non-small cell lung cancer (NSCLC) combined with a parametric survival model were developed to evaluate the ability of these modeling techniques to...
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