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Article

Quantitative modeling of tumor dynamics and development of drug resistance in non-small cell lung cancer patients treated with erlotinib.

CPT: pharmacometrics & systems pharmacology - 1 Apr 2024

Yin Anyue, Veerman G D Marijn, van Hasselt Johan G C, Steendam Christi M J, Dubbink Hendrikus Jan, Guchelaar Henk-Jan, Friberg Lena E, Dingemans Anne-Marie C, Mathijssen Ron H J, Moes Dirk Jan A R

Abstract excerpt

Insight into the development of treatment resistance can support the optimization of anticancer treatments. This study aims to characterize the tumor dynamics and development of drug resistance in patients with non-small cell lung cancer treated with erlotinib, and investigate the relationship between baseline circulating tumor DNA (ctDNA) data and tumor dynamics. Data obtained for the analysis included (1)...

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Share to Carcinoma, Non-Small-Cell Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38375997
DOI: 10.1002/psp4.13105
PMCID: PMC11015077

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