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Article

A retrospective examination of adjunctive L-methylfolate in children and adolescents with unipolar depression.

Journal of affective disorders - 1 Sept 2022

Bopp Emily A, Poweleit Ethan A, Cox Marley O, Farrow Jenni E, Strawn Jeffrey R, Patino Duran Luis R, Prows Cynthia A, DelBello Melissa P, Ramsey Laura B

Abstract excerpt

BACKGROUND: Adjunctive l-methylfolate is commonly prescribed for children and adolescents with treatment-resistant mood disorders; however, the relationship between l-methylfolate augmentation across methylenetetrahydrofolate reductase (MTHFR) genotypes in youths with depressive symptoms is unclear. METHODS: We retrospectively examined the electronic health records of patients (N = 412) with depressive symptoms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 35753502
DOI: 10.1016/j.jad.2022.06.039

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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