Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diterpenoid Caesalmin C Delays Aβ-Induced Paralysis Symptoms via the DAF-16 Pathway in Caenorhabditis elegans

20 Jun 2022

Abstract excerpt

Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease in the world. However, there is no effective drug to cure it. Caesalmin C is a cassane-type diterpenoid abundant in Caesalpinia bonduc (Linn.) Roxb. In this study, we investigated the effect of caesalmin C on Aβ-induced toxicity and possible mechanisms in the transgenic Caenorhabditis elegans AD model. Our results showed that caesalmin C...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pharmacological Effects of Natural Compounds
Share to Plant biochemistry and biosynthesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35743309
DOI: 10.3390/ijms23126871

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diterpenoid Caesalmin C Delays Aβ-Induced Paralysis Symptoms via the DAF-16 Pathway in Caenorhabditis elegansPMID 35743309Read ↗

Essential Oil of Acorus tatarinowii Schott Ameliorates Aβ-Induced Toxicity in Caenorhabditis elegans through an Autophagy PathwaySemantic proximity Read ↗

Otophylloside B Protects Against Aβ Toxicity in Caenorhabditis elegans Models of Alzheimer’s DiseaseSemantic proximity Read ↗

Natural Bioactive Products and Alzheimer’s Disease Pathology: Lessons from Caenorhabditis elegans Transgenic ModelsSemantic proximity Read ↗

<em>Caenorhabditis elegans</em> as a Model for Studying Nrf2/SKN-1 Activation in Alzheimer’s Disease: Plant Bioactive Compounds and Therapeutic TranslationSemantic proximity Read ↗

Inhibition of Abeta Proteotoxicity by Paeoniflorin in Caenorhabditis elegans Through Regulation of Oxidative and Heat Shock Stress ResponsesSemantic proximity Read ↗

Xanthoxyline prevents aging and neuronal damage by activating autophagy and DAF-16 expression in Caenorhabditis elegansSemantic proximity Read ↗

Caenorhabditis elegans as a possible model to screen anti-Alzheimer's therapeuticsSemantic proximity Read ↗

Effects of salvianolic acid A on β-amyloid mediated toxicity in <i>Caenorhabditis elegans</i> model of Alzheimer’s diseaseSemantic proximity Read ↗

Caralluma dalzielii as a Potential Therapy for Alzheimer’s Disease: Insights from a Transgenic Drosophila melanogaster ModelSemantic proximity Read ↗

Benzofuran–Chalcone Hybrids as Potential Multifunctional Agents against Alzheimer’s Disease: Synthesis and in vivo Studies with Transgenic <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

Disulfide-rich, cyclic peptides from <i>Clitoria ternatea</i> protect against β-amyloid toxicity and oxidative stress in transgenic <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

Sorbus alnifolia protects dopaminergic neurodegeneration in Caenorhabditis elegansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.