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Mutation of rpoS is Beneficial for Suppressing Organic Acid Secretion During 1,3-Propandiol Biosynthesis in Klebsiella pneumoniae.

Current microbiology - 15 Jun 2022

Dong Shufan, Liu Xuxia, Chen Tianyu, Zhou Xiaoqin, Li Shengming, Fu Shuilin, Gong Heng

Abstract excerpt

In this study, to reduce the formation of organic acid during 1,3-propanediol biosynthesis in Klebsiella pneumoniae, a method combining UV mutagenesis and high-throughput screening with pH color plates was employed to obtain K. pneumoniae mutants. When compared with the parent strain, the total organic acid formation by the mutant decreased, whereas 1,3-propanediol biosynthesis increased after 24 h anaerobic...

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PMID: 35704098
DOI: 10.1007/s00284-022-02901-w

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