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Article

A dynamic 3-factor survival model for acute myeloid leukemia that accounts for response to induction chemotherapy.

American journal of hematology - 1 Sept 2022

Tefferi Ayalew, Gangat Naseema, Al-Kali Aref, Alkhateeb Hassan, Shah Mithun, Patnaik Mrinal S, Elliott Michelle A, Hogan William J, Litzow Mark R, Hook Christopher C, Mangaonkar Abhishek, Viswanatha David, Chen Dong, Pardanani Animesh, Ketterling Rhett P, DiNardo Courtney D, Kadia Tapan M, Ravandi Farhad, Sasaki Koji, Begna Kebede H

Abstract excerpt

The current study was approached with the assumption that response to induction chemotherapy, in acute myeloid leukemia (AML), overshadows pre-treatment risk variables in predicting survival and therefore be used as an anchor for a simplified risk model. We considered 759 intensively-treated patients with AML, not promyelocytic: median age 60 years; primary 66%, secondary 25%, and therapy-related 9%; European...

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PMID: 35702875
DOI: 10.1002/ajh.26630

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